Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules
نویسندگان
چکیده
An in vitro model is described for studying the interaction between lymphocytes and high-endothelial venules (HEV) of lymph nodes. Rat or mouse lymphocytes which were layered over fixed sections of syngeneic lymph nodes adhered selectively to the endothelium of HEV but did not bind to other vascular endothelia. Evidence is presented that adherence to HEV in vitro is a property of recirculating lymphocytes and not a characteristic of cells which are unable to home into lymph nodes in vivo.
منابع مشابه
Brief Definitive Report LYMPHOCYTE HOMING INTO LYMPH NODES: IN VITRO DEMONSTRATION OF THE SELECTIVE AFFINITY OF RECIRCULATING LYMPHOCYTES FOR HIGH-ENDOTHELIAL VENULES*
Reci rcu la t ing lymphocytes e m i g r a t e from the blood into l y m p h nodes v ia a sys t em of special ized venu les which are d i s t ingu i shed by endo the l ium composed of t a l l cells con ta in ing l a rge pa le ves icu la r nucle i and a b u n d a n t cy toplasm. The si te of en t ry is specific for h igh -endo the l i a l venules (HEV) and no m i g r a t i o n of lymphocytes into...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 144 شماره
صفحات -
تاریخ انتشار 1976